Research solutions for COVID-19

The panel is a targeted gene expression profiling tool that contains 2,002 probes designed to identify genes involved in the body’s immune response to disease. This panel is equally suited to evaluate gene expression in response to autoimmune disease as it is to bacterial and viral infection, including infection from SARS-CoV-2 and the resulting COVID-19 disease.

• Evaluate pathways, processes, and cell types involved in disease, including immune system and cytokine dysregulation in response to pathogenic infection.
• Identify candidate targets involved in transcription, metabolism and viral defense
• Discover and validate disease- and therapeutic- specific biomarkers
• Measure responses to drug and immune therapy
• Elucidate therapeutic mechanism of action or validate drug targets
• Develop predictive signatures of infection and drug response
• Moure coverage than naostrings

Note: For nasopharyngeal swabs, RNA can be extracted fusing a standard RNA extraction kit or swab samples can be utilized following the HTG EdgeSeq extraction-free sample preparation.

Probes to genes involved in: Angiogenesis, endothelial activation, apoptosis, B-cell receptor signaling, cell cycle and proliferation, cell type markers, chemokine signaling, cytokines and cytokine dysregulation, cytotoxic receptors and function, DNA damage sensing and repair, epigenetics and transcriptional regulation, Fc receptors and phagocytosis, general immune response, immunometabolism, inflammasomes, lymphocyte trafficking, MCH Class I and Class II antigen presentation, mTOr signaling, NF-kB signaling, NOD-like receptor signaling, general interleukin signaling, oxidative stress, T-cell checkpoint modulation, T-cell receptor signaling, TGF-beta signaling, TH1/ TH2 / TH17 polarization and response, TNF signaling, Toll-like receptor signaling, Treg differentiation, Type I / Type II interferon signaling, vesicle and endocytosis.