Comprehensive Characterization of Immune Response to Disease
Measure Disease Progression with Innate Immune Response
Map New Biomarkers Using Expression of Autoimmune Disease
Targeted gene expression profiling is a powerful tool that can be used to identify autoimmune disease markers as well as the host immune response. Comparison of gene expression to normal samples can then be used to identify gene networks involved in disease progression.
Innate Pathogen Response and Pathway Identification
How cells respond to pathogen-mediated disruption of gene expression to initiate protective responses remains largely unclear. Targeting specific portions of the transcriptome involved in response can help researchers answer questions related to the pathogen-mediated disruption of gene expression as well as identify biomarkers involved in the innate immune response.
Characterize COVID-19 Disease Progression and Severity Through Gene Expression
Blanco-Melo et al. were the first peer reviewed publication to show that the transcription footprint of SARS-CoV-2 infection is distinct in comparison to the other viruses, including Respiratory Syncytial Virus (RSV), Human Parainfluenza Virus (HPIV) and Influenza A. While they noted that SARS-CoV-2 infection showed a robust chemokine signature, it failed to launch a robust IFN-I/-III response. These findings highlight the fundamental importance of gene expression profiling on understanding COVID-19 disease progression and severity.
Decode complexities of COVID-19 and other infectious diseases